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1996-03-09
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Document 0111
DOCN M9650111
TI Limited value of cerebrospinal fluid for direct detection of Toxoplasma
gondii in toxoplasmic encephalitis associated with AIDS.
DT 9605
AU Eggers C; Gross U; Klinker H; Schalke B; Stellbrink HJ; Kunze K;
Department of Neurology, University Hospital, Hamburg, Germany.
SO J Neurol. 1995 Oct;242(10):644-9. Unique Identifier : AIDSLINE
MED/96122571
AB The diagnosis of acquired immunodeficiency syndrome-associated
toxoplasmic encephalitis (TE), a typically focal disease resulting from
reactivation of tissue cysts, relies mainly on indirect diagnostic
methods. In a prospective study, we investigated the value of detection
of Toxoplasma gondii in cerebrospinal fluid (CSF) by using the
polymerase chain reaction and the mouse inoculation test. Twenty-four
patients with 26 episodes of TE, 2 HIV-infected patients with primary
acute Toxoplasma infection, and 38 HIV-infected control patients with
latent Toxoplasma infection were investigated. Detection of T. gondii in
CSF by both methods was possible in only 3 of the TE patients (11.5%),
the remaining patients being negative with either of the methods. In
contrast, T. gondii DNA was detected in both of the acutely infected
patients, indicating that in primary acute toxoplasmosis parasites may
easily be found in the CSF, whereas in the majority of TE cases in
immunocompromised patients, T. gondii parasites do not gain access to
the CSF drawn by lumbar puncture.
DE Adult Aged Animal AIDS-Related Opportunistic Infections/CEREBROSPINAL
FLUID/ COMPLICATIONS/*DIAGNOSIS/THERAPY Base Sequence Case-Control
Studies Encephalitis/CEREBROSPINAL FLUID/*DIAGNOSIS/ETIOLOGY/THERAPY
Female Human Male Middle Age Molecular Sequence Data *Polymerase
Chain Reaction Predictive Value of Tests Prospective Studies Support,
Non-U.S. Gov't Toxoplasma/*ISOLATION & PURIF
Toxoplasmosis/CEREBROSPINAL FLUID/COMPLICATIONS/*DIAGNOSIS/ THERAPY
Treatment Outcome JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).